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Article

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma.

Gut - 1 Mar 2019

Lee Alex Y L, Dubois Claire L, Sarai Karnjit, Zarei Soheila, Schaeffer David F, Sander Maike, Kopp Janel L

Abstract excerpt

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumour thought to arise from ductal cells via pancreatic intraepithelial neoplasia (PanIN) precursor lesions. Modelling of different genetic events in mice suggests both ductal and acinar cells can give rise to PDAC. However, the impact of cellular context alone on tumour development and phenotype is unknown. DESIGN: We examined the...

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Share to Acinar Cells
Share to Carcinoma in Situ
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Neoplasm Grading

Share to Pancreatic Neoplasms

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Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 29363536
DOI: 10.1136/gutjnl-2017-314426
PMCID: PMC11529381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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