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Article

Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Aug 2024

Yasin Saif, Lesko Sydney L, Kharytonchyk Siarhei, Brown Joshua D, Chaudry Issac, Geleta Samuel A, Tadzong Ndeh F, Zheng Mei Y, Patel Heer B, Kengni Gabriel, Neubert Emma, Quiambao Jeanelle Mae C, Becker Ghazal, Ghinger Frances Grace, Thapa Sreeyasha, Williams A'Lyssa, Radov Michelle H, Boehlert Kellie X, Hollmann Nele M, Singh Karndeep, Bruce James W, Marchant Jan, Telesnitsky Alice, Sherer Nathan M, Summers Michael F

Abstract excerpt

HIV-1 transcript function is controlled in part by twinned transcriptional start site usage, where 5' capped RNAs beginning with a single guanosine (1G) are preferentially packaged into progeny virions as genomic RNA (gRNA) whereas those beginning with three sequential guanosines (3G) are retained in cells as mRNAs. In 3G transcripts, one of the additional guanosines base pairs with a cytosine located within a...

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Genome, Viral
HIV-1
Nucleic Acid Conformation
Protein Biosynthesis

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PMID: 39110735
DOI: 10.1073/pnas.2407400121
PMCID: PMC11331132

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