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Article

Unpaired Guanosines in the 5' Untranslated Region of HIV-1 RNA Act Synergistically To Mediate Genome Packaging.

Journal of virology - 14 Oct 2020

Nikolaitchik Olga A, Somoulay Xayathed, Rawson Jonathan M O, Yoo Jennifer A, Pathak Vinay K, Hu Wei-Shau

Abstract excerpt

The viral protein Gag selects full-length HIV-1 RNA from a large pool of mRNAs as virion genome during virus assembly. Currently, the precise mechanism that mediates the genome selection is not understood. Previous studies have identified several sites in the 5' untranslated region (5' UTR) of HIV-1 RNA that are bound by nucleocapsid (NC) protein, which is derived from Gag during virus maturation. However,...

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Identifiers

PMID: 32796062
DOI: 10.1128/JVI.00439-20
PMCID: PMC7565613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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