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Article

HIV-1 single-transcription start-site mutants display complementary replication functions that are restored by reversion.

Journal of virology - 15 Apr 2025

Gc K, Lesko S, Emery A, Burnett C, Gopal K, Clark S, Swanstrom R, Sherer N M, Telesnitsky A, Kharytonchyk S

Abstract excerpt

HIV-1 transcription initiates at two positions, generating RNAs with either cap1G or cap3G 5' ends. The replication fates of these RNAs differ, with viral particles encapsidating almost exclusively cap1G RNAs and cap3G RNAs retained in cells where they are enriched on polysomes and among spliced viral RNAs. Here, we studied replication properties of virus promoter mutants that produced only one RNA 5' isoform or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

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Identifiers

PMID: 40035516
DOI: 10.1128/jvi.02139-24
PMCID: PMC11998490

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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