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Article

Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis.

Journal of biomedical science - 5 Aug 2024

Cufré Mónica, Pastorini Mercedes, Martín Ignacio, Failde Rodrigo, Palmero Domingo, Alemán Mercedes

Abstract excerpt

BACKGROUND: Dectin-1 is a transmembrane receptor that plays a pivotal role in recognising fungi and Mycobacterium tuberculosis (Mtb). A specific variant, DECTIN-1 rs16910526, results in a truncated receptor that disrupts membrane expression and ligand binding and is clinically associated with recurrent cutaneous mycoses. Previous research has clarified the role of Dectin-1 in boosting immune defenses against...

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Identifiers

PMID: 39103844
DOI: 10.1186/s12929-024-01067-w
PMCID: PMC11302830

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