Article
CD209 genetic polymorphism and tuberculosis disease.
PloS one - 2 Jan 2008
Vannberg Fredrik O, Chapman Stephen J, Khor Chiea C, Tosh Kerrie, Floyd Sian, Jackson-Sillah Dolly, Crampin Amelia, Sichali Lifted, Bah Boubacar, Gustafson Per, Aaby Peter, McAdam Keith P W J, Bah-Sow Oumou, Lienhardt Christian, Sirugo Giorgio, Fine Paul, Hill Adrian V S
Abstract excerpt
BACKGROUND: Tuberculosis causes significant morbidity and mortality worldwide, especially in sub-Saharan Africa. DC-SIGN, encoded by CD209, is a receptor capable of binding and internalizing Mycobacterium tuberculosis. Previous studies have reported that the CD209 promoter single nucleotide polymorphism (SNP)-336A/G exerts an effect on CD209 expression and is associated with human susceptibility to dengue, HIV-1...
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