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Article

Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.

PloS one - 1 Jan 2012

Sainz Juan, Lupiáñez Carmen Belén, Segura-Catena Juana, Vazquez Lourdes, Ríos Rafael, Oyonarte Salvador, Hemminki Kari, Försti Asta, Jurado Manuel

Abstract excerpt

The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi. The present study was designed to investigate whether the presence of single nucleotide polymorphisms (SNPs) within DC-SIGN, Dectin-1, Dectin-2, CCL2 and CCR2 genes influence the risk of developing Invasive Pulmonary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22384201
DOI: 10.1371/journal.pone.0032273
PMCID: PMC3288082

Genes

CCL2
CCR2

Provenance

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