The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina.

doi:10.1038/srep40666

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The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina.

Scientific reports - 18 Jan 2017

Rolandelli A, Hernández Del Pino R E, Pellegrini J M, Tateosian N L, Amiano N O, de la Barrera S, Casco N, Gutiérrez M, Palmero D J, García V E

Abstract excerpt

Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional...

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PMID: 28098168
DOI: 10.1038/srep40666
PMCID: PMC5241634

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