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SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus

24 Jul 2024

Abstract excerpt

Through genome-wide association studies (GWAS) and integrated expression quantitative trait locus (eQTL) analyses, numerous susceptibility genes (“eGenes”, whose expressions are significantly associated with common variants) associated with systemic lupus erythematosus (SLE) have been identified. Notably, a subset of these eGenes is correlated with disease activity. However, the precise mechanisms through which...

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PMID: 39099414
DOI: 10.3724/abbs.2024132

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