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Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus

11 Feb 2019

Abstract excerpt

Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous lupus erythematosus [CLE]). There are limited treatment options for SLE and no Food and Drug Administration–approved therapies for CLE. Studies have revealed that IFNs are important mediators for SLE and CLE, but the mechanisms by...

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PMID: 30745462
DOI: 10.4049/jimmunol.1800650

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