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Article

[Infection stress and a driver mutation interact to promote transformation to hematological malignancies].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024

Sashida Goro

Abstract excerpt

Myelodysplastic syndrome (MDS) is a refractory cancer that arises from hematopoietic stem cells and predominantly affects elderly adults. In addition to driver gene mutations, which are also found in clonal hematopoiesis in healthy elderly people, systemic inflammation caused by infection or collagen disease has long been known as an extracellular factor in the pathogenesis of MDS. Wild-type HSCs have an "innate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39098022
DOI: 10.11406/rinketsu.65.702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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