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A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

13 Sept 2019

Abstract excerpt

Leukemia stem cells are a rare population with a primitive progenitor phenotype that can initiate, sustain, and recapitulate leukemia through a poorly understood mechanism of self-renewal. Here, we report that Krüppel-like factor 4 (KLF4) promotes disease progression in a murine model of chronic myeloid leukemia (CML)-like myeloproliferative neoplasia by repressing an inhibitory mechanism of preservation in...

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PMID: 31515251
DOI: 10.1182/blood.2018875922

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