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Article

Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.

Annals of hematology - 1 Feb 2015

Yi Sha, Wen Lu, He Jing, Wang Youping, Zhao Fei, Zhao Jie, Zhao Zichu, Cui Guohui, Chen Yan

Abstract excerpt

Nucleophosmin (NPM1) is a multifunctional protein that functions as a molecular chaperone, shuttling between the nucleolus and the cytoplasm. In up to one third of patients with acute myeloid leukemia, mutation of NPM1 results in the aberrant cytoplasmic accumulation of mutant protein and is thou...

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Source

Identifiers

PMID: 25242579
DOI: 10.1007/s00277-014-2206-x

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25242579-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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