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Article

The effect of small molecule inhibitor NSC348884 on nucleophosmin 1-mutated acute myeloid leukemia cells.

European review for medical and pharmacological sciences - 1 Oct 2023

Zhu J-F, Han L-L, Ma Y, Wang Y-X, Zhang F

Abstract excerpt

OBJECTIVE: Nucleophosmin 1 (NPM1) is a common shuttling protein. Mutation in the NPM1 gene is the most frequent gene alteration in acute myeloid leukemia (AML). This study aims to explore the inhibitory effects of small molecule NSC348884 on wild-type and NPM1-mutated AML cells. MATERIALS AND METHODS: Immunofluorescence was used to determine the intracellular localization of NPM1 protein in wild-type (OCI-AML2)...

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PMID: 37843328
DOI: 10.26355/eurrev_202310_33940

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