Article
Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition.
Blood - 28 Oct 2010
Leong Sai Mun, Tan Ban Xiong, Bte Ahmad Baidah, Yan Tie, Chee Lai Yuen, Ang Swee Tin, Tay Kian Ghee, Koh Liang Piu, Yeoh Allen Eng Juh, Koay Evelyn Siew-Chuan, Mok Yu-Keung, Lim Tit Meng
Abstract excerpt
In up to one-third of patients with acute myeloid leukemia, a C-terminal frame-shift mutation results in abnormal and abundant cytoplasmic accumulation of the usually nucleoli-bound protein nucleophosmin (NPM), and this is thought to function in cancer pathogenesis. Here, we demonstrate a gain-of-function role for cytoplasmic NPM in the inhibition of caspase signaling. The NPM mutant specifically inhibits the...
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