Article
Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia.
Cancer - 1 May 2017
Nabbouh Ali I, Hleihel Rita S, Saliba Jessica L, Karam Martin M, Hamie Maguy H, Wu Hsin-Chieh J M, Berthier Caroline P, Tawil Nadim M, Bonnet Pierre-Antoine A, Deleuze-Masquefa Carine, El Hajj Hiba A
Abstract excerpt
BACKGROUND: Nucleophosmin 1 (NPM1) is a nucleocytoplasmic shuttling protein mainly localized in the nucleolus. NPM1 is frequently mutated in acute myeloid leukemia (AML). NPM1c oligomerizes with wild-type nucleophosmin 1 (wt-NPM1), and this leads to its continuous cytoplasmic delocalization and contributes to leukemogenesis. Recent studies have shown that Cytoplasmic NPM1 (NPM1c) degradation leads to growth...
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