Article
Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells.
Blood - 28 May 2015
El Hajj Hiba, Dassouki Zeina, Berthier Caroline, Raffoux Emmanuel, Ades Lionel, Legrand Olivier, Hleihel Rita, Sahin Umut, Tawil Nadim, Salameh Ala, Zibara Kazem, Darwiche Nadine, Mohty Mohamad, Dombret Hervé, Fenaux Pierre, de Thé Hugues, Bazarbachi Ali
Abstract excerpt
Nucleophosmin-1 (NPM1) is the most frequently mutated gene in acute myeloid leukemia (AML). Addition of retinoic acid (RA) to chemotherapy was proposed to improve survival of some of these patients. Here, we found that RA or arsenic trioxide synergistically induce proteasomal degradation of mutant NPM1 in AML cell lines or primary samples, leading to differentiation and apoptosis. NPM1 mutation not only...
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