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Article

Modeling study of kinesin-13 MCAK microtubule depolymerase.

European biophysics journal : EBJ - 1 Aug 2024

Xie Ping

Abstract excerpt

Mitotic centromere-associated kinesin (MCAK) motor protein is a typical member of the kinesin-13 family, which can depolymerize microtubules from both plus and minus ends. A critical issue for the MCAK motor is how it performs the depolymerase activity. To address the issue, the pathway of the MCAK motor moving on microtubules and depolymerizing the microtubules is presented here. On the basis of the pathway, the...

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PMID: 39093405
DOI: 10.1007/s00249-024-01718-8

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