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Article

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.

Nature communications - 10 Jul 2017

Wang Weiyi, Cantos-Fernandes Soraya, Lv Yuncong, Kuerban Hureshitanmu, Ahmad Shoeb, Wang Chunguang, Gigant Benoît

Abstract excerpt

Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state and bound to the αβ-tubulin heterodimer, a complex mimicking the species that dissociates from microtubule ends during catalytic disassembly. Our results picture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28694425
DOI: 10.1038/s41467-017-00091-9
PMCID: PMC5503940

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