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Article

K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant.

The Journal of cell biology - 25 Nov 2002

Ovechkina Yulia, Wagenbach Michael, Wordeman Linda

Abstract excerpt

Unlike most kinesins, mitotic centromere-associated kinesin (MCAK) does not translocate along the surface of microtubules (MTs), but instead depolymerizes them. Among the motile kinesins, refinements that are unique for specific cellular functions, such as directionality and processivity, are under the control of a "neck" domain adjacent to the ATP-hydrolyzing motor domain. Despite its apparent lack of motility,...

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Identifiers

PMID: 12446739
DOI: 10.1083/jcb.200205089
PMCID: PMC2173087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant.PMID 12446739Read ↗

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