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Article

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.

Open biology - 1 Oct 2016

Patel Jennifer T, Belsham Hannah R, Rathbone Alexandra J, Wickstead Bill, Gell Christopher, Friel Claire T

Abstract excerpt

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize the microtubule end. This ability is key to the action of MCAK in regulating microtubule dynamics. We show that the α4-helix of the motor domain is crucial to...

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Identifiers

PMID: 27733589
DOI: 10.1098/rsob.160223
PMCID: PMC5090061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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