Article
Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice.
Cell reports - 3 Mar 2020
Forte Elvira, Skelly Daniel A, Chen Mandy, Daigle Sandra, Morelli Kaesi A, Hon Olivia, Philip Vivek M, Costa Mauro W, Rosenthal Nadia A, Furtado Milena B
Abstract excerpt
Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process that culminates in the formation of a scar whose structural characteristics dictate propensity to favorable healing or detrimental cardiac wall rupture. To elucidate the cellular processes underlying scar formation, here we perform unbiased single-cell mRNA sequencing of interstitial cells isolated from infarcted mouse...
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