Characterization of a high‐affinity human antibody with a disulfide bridge in the third complementarity‐determining region of the heavy chain

Abstract excerpt

Disulfide bridges are common in the antigen-binding site from sharks (new antigen receptor) and camels (single variable heavy-chain domain, VHH), in which they confer both structural diversity and domain stability. In human antibodies, cysteine residues in the third complementarity-determining region of the heavy chain (CDR-H3) are rare but naturally encoded in the IGHD germline genes. Here, by panning a phage...

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• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• T-cell and B-cell Immunology