Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 genotypic resistance testing using single molecule real-time sequencing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2024

Raymond Stéphanie, Jeanne Nicolas, Vellas Camille, Nicot Florence, Saune Karine, Ranger Noémie, Latour Justine, Carcenac Romain, Harter Agnès, Delobel Pierre, Izopet Jacques

Abstract excerpt

BACKGROUND: HIV-1 resistance testing is recommended in clinical management and next-generation sequencing (NGS) methods are now available in many virology laboratories. OBJECTIVES: To evaluate the diagnostic performance of Long-Read Single Molecule Real-time (SMRT) sequencing (Sequel, PacBio) for HIV-1 polymerase genotyping. STUDY DESIGN: 111 prospective clinical samples (83 plasma and 28 leukocyte-enriched blood...

Topics

HIV-1
Humans
HIV Infections
Drug Resistance, Viral
High-Throughput Nucleotide Sequencing
Genotype
Viral Load
Prospective Studies
Genotyping Techniques
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Anti-HIV Agents

Microbial Sensitivity Tests

Sensitivity and Specificity

Sequence Analysis, DNA

Mutation

Source

Identifiers

PMID: 39068746
DOI: 10.1016/j.jcv.2024.105717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39068746-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 genotypic resistance testing using single molecule real-time sequencing.PMID 39068746Read ↗

Comparison of short-read and long-read next-generation sequencing technologies for determining HIV-1 drug resistance.Semantic proximity Read ↗

Resistance profile of HIV-1 quasispecies in patients under treatment failure using single molecule, real-time sequencing.Semantic proximity Read ↗

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.Semantic proximity Read ↗

Full-spectrum HIV drug resistance mutation detection by high-resolution complete pol gene sequencing.Semantic proximity Read ↗

RNA and DNA Sanger sequencing versus next-generation sequencing for HIV-1 drug resistance testing in treatment-naive patients.Semantic proximity Read ↗

HIV-1 gag genotypic resistance testing using short-read and long-read next-generation sequencing technologies.Semantic proximity Read ↗

Performance of a high-throughput next-generation sequencing method for analysis of HIV drug resistance and viral load.Semantic proximity Read ↗

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance.Semantic proximity Read ↗

Technologies for HIV-1 drug resistance testing: inventory and needs.Semantic proximity Read ↗

HIV-1 DNA Testing in Viremic Patients Identifies More Drug Resistance Than HIV-1 RNA TestingSemantic proximity Read ↗

HIV DNA Sequencing to Detect Archived Antiretroviral Drug ResistanceSemantic proximity Read ↗

New Aspects of the Virus Life Cycle and Clinical Utility of Next Generation Sequencing based HIV-1 Resistance Testing in the Genomic, the Proviral, and the Viral Reservoir of Peripheral Blood Mononuclear Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.