Induction of specific base-pair substitutions in E. coli trpA mutants by chloroethylene oxide, a carcinogenic vinyl chloride metabolite.

doi:10.1016/0027-5107(85)90056-9

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Article

Induction of specific base-pair substitutions in E. coli trpA mutants by chloroethylene oxide, a carcinogenic vinyl chloride metabolite.

Mutation research - 1 Jan 2000

Barbin A, Besson F, Perrard M H, Béréziat J C, Kaldor J, Michel G, Bartsch H

Abstract excerpt

Chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, induces base-pair substitution mutations but not frameshift mutations in bacteria. The mutational specificity of CEO was investigated in Escherichia coli, using the trpA mutants developed by Yanofsky. Reversion fre...

Topics

Alleles
Base Composition
Carcinogens
Escherichia coli
Ethylene Oxide
Genes
Genes, Bacterial
Mutagenicity Tests
Mutagens
Mutation
Tryptophan Synthase

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