recA-independent mutagenicity induced by chloroethylene oxide in E. coli.

doi:10.1016/0027-5107(85)90057-0

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Article

recA-independent mutagenicity induced by chloroethylene oxide in E. coli.

Mutation research - 1 Jan 2000

Barbin A, Tenenbaum L, Toman Z, Radman M, Bartsch H

Abstract excerpt

The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinatio...

Topics

Escherichia coli
Ethylene Oxide
Kinetics
Mutagenicity Tests
Mutagens
Mutation
Rec A Recombinases
Species Specificity

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