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Article

Inferring causal direction between two traits using R2 with application to transcriptome-wide association studies.

American journal of human genetics - 8 Aug 2024

Liao Huiling, Xue Haoran, Pan Wei

Abstract excerpt

In Mendelian randomization, two single SNP-trait correlation-based methods have been developed to infer the causal direction between an exposure (e.g., a gene) and an outcome (e.g., a trait), called MR Steiger's method and its recent extension called Causal Direction-Ratio (CD-Ratio). Here we propose an approach based on R2, the coefficient of determination, to combine information from multiple (possibly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39053457
DOI: 10.1016/j.ajhg.2024.06.013
PMCID: PMC11339628

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CAD

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