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Article

Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva.

Current osteoporosis reports - 1 Jun 2011

Shore Eileen M, Kaplan Frederick S

Abstract excerpt

Heterotopic ossification is a pathologic condition in which bone tissue is formed outside of the skeleton, within soft tissues of the body. The extraskeletal bone that forms in these disorders is normal; the cellular mechanisms that direct cell fate decisions are dysregulated. Patients with fibrodysplasia ossificans progressiva (FOP), a rare human genetic disorder of extensive and progressive heterotopic...

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Source

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Identifiers

PMID: 21340697
DOI: 10.1007/s11914-011-0046-3
PMCID: PMC3433752

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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