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Article

Identification of genetic variants associated with idiopathic inflammatory myopathies via cross-trait analysis with B cell lymphomas.

HGG advances - 8 Oct 2026

Che Weng Ian, Jarvis James N, Sysojev Anton Öberg, Zhu Catherine, Patasova Karina, Smedby Karin E, Lundberg Ingrid E, Westerlind Helga, Lamb Janine A, Holmqvist Marie

Abstract excerpt

The genetic architecture of idiopathic inflammatory myopathies (IIMs) remains incompletely defined. When increasing sample size is not feasible, cross-trait analysis of genetically correlated diseases offers an effective strategy for discovering risk loci. Using summary statistics of IIM and B cell lymphoma subtypes, we applied conditional false discovery rate (condFDR) and multi-trait analysis of genome-wide...

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Identifiers

PMID: 42499187
DOI: 10.1016/j.xhgg.2026.100658
PMCID: PMC13495596

Genes

DGKQ
ORMDL3
ATP23
COL4A1
DUSP22
GSDMB
IDUA
IKZF3
PGAP3
PSMD3
SLC26A1
SPON2
STARD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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