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Article

Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots.

Nature communications - 23 Jul 2024

Kompella Pallavi, Wang Guliang, Durrett Russell E, Lai Yanhao, Marin Celeste, Liu Yuan, Habib Samy L, DiGiovanni John, Vasquez Karen M

Abstract excerpt

Obesity is associated with increased cancer risk, yet the underlying mechanisms remain elusive. Obesity-associated cancers involve disruptions in metabolic and cellular pathways, which can lead to genomic instability. Repetitive DNA sequences capable of adopting alternative DNA structures (e.g., H-DNA) stimulate mutations and are enriched at mutation hotspots in human cancer genomes. However, it is not known if...

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Identifiers

PMID: 39043652
DOI: 10.1038/s41467-024-50006-8
PMCID: PMC11266421

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MYC

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