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Article

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet.

Scientific reports - 26 Aug 2023

Meyenberg Mathilde, Hakobyan Anna, Papac-Milicevic Nikolina, Göderle Laura, Langner Franziska L, Markovic Mateo, Lee Ji-Hyun, Koo Bon-Kyoung, Busslinger Georg A, da Silva Israel Tojal, Binder Christoph J, Menche Jörg, Loizou Joanna I

Abstract excerpt

Obesity is a modifiable risk factor in cancer development, especially for gastrointestinal cancer. While the etiology of colorectal cancer is well characterized by the adenoma-carcinoma sequence, it remains unclear how obesity influences colorectal cancer development. Dietary components of a high fat diet along with obesity have been shown to modulate the cancer risk by perturbing the homeostasis of intestinal...

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Identifiers

PMID: 37633982
DOI: 10.1038/s41598-023-41123-3
PMCID: PMC10460443

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