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EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s

23 Jul 2024

Abstract excerpt

Tumor-derived prostaglandin E2 (PGE2) impairs antitumor immunity by priming suppressive functions on various immune cell types, including dendritic cells (DCs). In this way, tumors mediate DC dysfunction and hamper their antitumoral activity. PGE2 is known to modulate DC function via signaling through the E-type prostanoid receptor 2 (EP2) and EP4. Preclinical studies have demonstrated the therapeutic value of...

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PMID: 39041661
DOI: 10.1093/jleuko/qiae164

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