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Article

The Phenotypical and Functional Effect of PGE2 on Human Macrophages.

European journal of immunology - 1 Nov 2025

Pfirrmann Maren, Bödder Johanna, Wuestenenk Rowan, Tennebroek Jesse, Lyer Kirti K, Poel Dennis, Tauriello Daniele V F, Verdoes Martijn, de Vries I Jolanda M

Abstract excerpt

Prostaglandin E2 (PGE2) is one important immunosuppressive factor within the tumor microenvironment (TME). Signaling through E-prostanoid receptor type 2 (EP2) and EP4, PGE2 promotes suppressive immune cell phenotypes and impairs antitumor immunity. Blocking PGE2 signaling with EP2 and EP4 antagonists is explored to counteract tumor-induced immunosuppression. While tumor-derived PGE2 is known to modulate human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41211769
DOI: 10.1002/eji.70090
PMCID: PMC12599275

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