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Article

Intracellular EP2 prostanoid receptor promotes cancer-related phenotypes in PC3 cells.

Cellular and molecular life sciences : CMLS - 1 Sept 2015

Fernández-Martínez Ana Belén, Lucio-Cazaña Javier

Abstract excerpt

Prostaglandin E2 (PGE2) and hypoxia-inducible factor-1α (HIF-1α) affect many mechanisms that have been involved in the pathogenesis of prostate cancer (PC). HIF-1α, which is up-regulated by PGE2 in LNCaP cells and PC3 cells, has been shown to contribute to metastasis and chemo-resistance of castrate-resistant PC (a lethal form of PC) and to promote in PC cells migration, invasion, angiogenesis and...

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Identifiers

PMID: 25828575
DOI: 10.1007/s00018-015-1891-5
PMCID: PMC11113933

Genes

EGFR

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