Article
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2003
Sharma Sherven, Stolina Marina, Yang Seok-Chul, Baratelli Felicita, Lin Jeff F, Atianzar Kimberly, Luo Jie, Zhu Li, Lin Ying, Huang Min, Dohadwala Mariam, Batra Raj K, Dubinett Steven M
Abstract excerpt
Dendritic cells (DCs) serve as professional antigen-presenting cells and are pivotal in the host immune response to tumor antigens. To define the pathways limiting DC function in the tumor microenvironment, we assessed the impact of tumor cyclooxygenase (COX)-2 expression on DC activities. Bone marrow-derived DCs were cultured in either tumor supernatant (TSN) or TSN from COX-2-inhibited tumors. After culture,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.