Article
cDC2 plasticity and acquisition of a DC3-like phenotype mediated by IL-6 and PGE2 in a patient-derived colorectal cancer organoids model.
European journal of immunology - 1 Jun 2024
Subtil Beatriz, van der Hoorn Iris A E, Cuenca-Escalona Jorge, Becker Anouk M D, Alvarez-Begue Mar, Iyer Kirti K, Janssen Jorien, van Oorschot Tom, Poel Dennis, Gorris Mark A J, van den Dries Koen, Cambi Alessandra, Tauriello Daniele V F, de Vries I Jolanda M
Abstract excerpt
Metastatic colorectal cancer (CRC) is highly resistant to therapy and prone to recur. The tumor-induced local and systemic immunosuppression allows cancer cells to evade immunosurveillance, facilitating their proliferation and dissemination. Dendritic cells (DCs) are required for the detection, processing, and presentation of tumor antigens, and subsequently for the activation of antigen-specific T cells to...
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