Article

Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer

2023-02-08

Abstract excerpt

Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, linking ribosome biogenesis plasticity with tumor cell fate, we uncover that the amino acid sensor GCN2 represses the expression of the precursor of ribosomal RNA, 47S, unde...

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Literature Corpus work: 8060d1c7-3add-5344-aa0b-109ccdb84f4a
DOI: 10.1101/2023.02.08.527626

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