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Article

Construction of a high-efficiency GjCCD4a mutant and its application for de novo biosynthesis of five crocins in Escherichia coli.

International journal of biological macromolecules - 1 Oct 2024

Li Siqi, Zhou Ze, Li Yufang, Hu Yan, Huang Ziyi, Hu Ge, Wang Ying, Wang Xu, Lou Qian, Gao Longlong, Shen Chuanpu, Gao Ranran, Xu Zhichao, Song Jingyuan, Pu Xiangdong

Abstract excerpt

Crocins are bioactive natural products that rarely exist in plants. High costs and resource shortage severely limit its development and application. Synthetic biology studies on crocins are of considerable global interest. However, the lack of high-efficiency genetic tools and complex cascade biocatalytic systems have substantially hindered progress in crocin biosynthesis-related research. Based on mutagenesis, a...

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PMID: 39033887
DOI: 10.1016/j.ijbiomac.2024.133985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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