Article

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms

2025-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Myelodysplastic neoplasms (MDS) disrupt bone marrow hematopoiesis, yet clinical assessment relies largely on blast enumeration and qualitative morphology, which incompletely capture marrow architecture and disease state. We applied whole-slide multiplex immunofluorescence imaging with single-cell phenotyping to map bone marrow microarchitecture in MDS. Diagnostic biopsies (n=36), longitudinal tr...

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Literature Corpus work: 4185be0d-bcd1-5bf0-89e4-7e9e9b1684a1
DOI: 10.1101/2025.10.02.680138

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