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Article

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

Cell metabolism - 1 Aug 2007

Jing Enxuan, Gesta Stephane, Kahn C Ronald

Abstract excerpt

The family of mammalian Sirtuin proteins comprises seven members homologous to yeast Sir2. Here we show that SIRT2, a cytoplasmic sirtuin, is the most abundant sirtuin in adipocytes. Sirt2 expression is downregulated during preadipocyte differentiation in 3T3-L1 cells. Overexpression of SIRT2 inhibits differentiation, whereas reducing SIRT2 expression promotes adipogenesis. Both effects are accompanied by...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17681146
DOI: 10.1016/j.cmet.2007.07.003
PMCID: PMC2083635

Genes

SIRT2
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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