Article
A MRSA mystery: how PBP4 and cyclic-di-AMP join forces against β-lactam antibiotics.
mBio - 14 Aug 2024
Gardner Taylor M, Grosser Melinda R
Abstract excerpt
The high-level resistance to next-generation β-lactams frequently found in Staphylococcus aureus isolates lacking mec, which encodes the transpeptidase PBP2a traditionally associated with methicillin-resistant Staphylococcus aureus (MRSA), has remained incompletely understood for decades. A new study by Lai et al. found that the co-occurrence of mutations in pbp4 and gdpP, which respectively cause increased...
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