A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.

doi:10.1128/AAC.00594-10

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Article

A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.

Antimicrobial agents and chemotherapy - 1 Nov 2010

Banerjee Ritu, Gretes Michael, Harlem Christopher, Basuino Li, Chambers Henry F

Abstract excerpt

We previously generated a ceftobiprole-resistant Staphylococcus aureus strain after high inoculum serial passage of a mecA-negative variant of strain COL (R. Banerjee, M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers, Antimicrob. Agents Chemother. 52:2089-2096, 2008). Genome resequencing of this strain, CRB, revealed that it differs from its parent by five single-nucleotide polymorphisms in three genes,...

Topics

Bacterial Proteins
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Mutation
Penicillin-Binding Proteins
beta-Lactam Resistance
beta-Lactams

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Identifiers

PMID: 20805396
DOI: 10.1128/AAC.00594-10
PMCID: PMC2976154

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