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Article

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2017

Dieffenbach Paul B, Haeger Christina Mallarino, Coronata Anna Maria F, Choi Kyoung Moo, Varelas Xaralabos, Tschumperlin Daniel J, Fredenburgh Laura E

Abstract excerpt

Pulmonary arterial stiffness is an independent risk factor for mortality in pulmonary hypertension (PH) and plays a critical role in PH pathophysiology. Our laboratory has recently demonstrated arterial stiffening early in experimental PH, along with evidence for a mechanobiological feedback loop by which arterial stiffening promotes further cellular remodeling behaviors (Liu F, Haeger CM, Dieffenbach PB, Sicard...

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Share to Airway Remodeling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Hypertension, Pulmonary

Share to Myocytes, Smooth Muscle

Share to Pulmonary Artery

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Source

Open in PubMed Open full text

Identifiers

PMID: 28642262
DOI: 10.1152/ajplung.00173.2017
PMCID: PMC5625262

Genes

PAH
WWTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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