Article
Endothelial-to-mesenchymal transition in pulmonary hypertension.
Circulation - 17 Mar 2015
Ranchoux Benoît, Antigny Fabrice, Rucker-Martin Catherine, Hautefort Aurélie, Péchoux Christine, Bogaard Harm Jan, Dorfmüller Peter, Remy Séverine, Lecerf Florence, Planté Sylvie, Chat Sophie, Fadel Elie, Houssaini Amal, Anegon Ignacio, Adnot Serge, Simonneau Gerald, Humbert Marc, Cohen-Kaminsky Sylvia, Perros Frédéric
Abstract excerpt
BACKGROUND: The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS: In situ evidence of EndoMT in human PAH was...
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