JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.

Abstract excerpt

Joint association analysis of multiple traits with multiple genetic variants can provide insight into genetic architecture and pleiotropy, improve trait prediction, and increase power for detecting association. Furthermore, some traits are naturally high-dimensional, e.g., images, networks, or longitudinally measured traits. Assessing significance for multitrait genetic association can be challenging, especially...

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