Article

A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies

2023-11-02

Abstract excerpt

Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS rare variant association analysis can improve statistical power over single-trait analysis, and also detect pleiotropic genes and regions. Existing multi-trait methods have limited abil...

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Literature Corpus work: 38fa3895-86d7-5ff9-bced-27c1c0ca4529
DOI: 10.1101/2023.10.30.564764

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