Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

doi:10.1021/cb500149m

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Article

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

ACS chemical biology - 18 Jul 2014

Albesa-Jové David, Chiarelli Laurent R, Makarov Vadim, Pasca Maria Rosalia, Urresti Saioa, Mori Giorgia, Salina Elena, Vocat Anthony, Comino Natalia, Mohorko Elisabeth, Ryabova Svetlana, Pfieiffer Bernhard, Lopes Ribeiro Ana Luisa de Jesus, Rodrigo-Unzueta Ane, Tersa Montse, Zanoni Giuseppe, Buroni Silvia, Altmann Karl-Heinz, Hartkoorn Ruben C, Glockshuber Rudi, Cole Stewart T, Riccardi Giovanna, Guerin Marcelo E

Abstract excerpt

The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis highlights the need to discover new antitubercular agents. Here we describe the synthesis and characterization of a new series of thienopyrimidine (TP) compounds that kill both replicating and non-replicating M. tuberculosis. The strategy to determine the mechanism of action of these TP derivatives was to generate...

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PMID: 24877756
DOI: 10.1021/cb500149m

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