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Article

Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle-cell squamous cell carcinoma.

The Journal of pathology - 1 Sept 2024

Wang Yulu, Zhu Qian, Wu Yaqing, Li Boyi, Su Xiaoxing, Xiang Chan, Han Yuchen

Abstract excerpt

Esophageal spindle-cell squamous cell carcinoma (ESS) is a rare biphasic neoplasm composed of a carcinomatous component (CaC) and a sarcomatous component (SaC). However, the genomic origin and gene signature of ESS remain unclear. Using whole-exome sequencing of laser-capture microdissection (LCM) tumor samples, we determined that CaC and SaC showed high mutational commonality, with the same top high-frequency...

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Identifiers

PMID: 39022845
DOI: 10.1002/path.6324

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