Article
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic mutations.
The Journal of pathology - 1 Feb 2023
Li Yan, Liu Linxiu, Pan Yi, Fang Fang, Xie Tongji, Cheng Na, Guo Changyuan, Xue Xuemin, Zeng Hua, Xue Liyan
Abstract excerpt
Esophageal basaloid squamous cell carcinoma (bSCC) is a subtype of squamous cell carcinoma (SCC) with a different behavior and poor prognosis. Exploring bSCC's molecular characteristics and treatment strategies are of great clinical significance. We performed multi-omics analysis of paired bSCC and common SCC (cSCC) using whole exome sequencing and a NanoString nCounter gene expression panel. Immunohistochemistry...
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