Article
Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy.
Genome medicine - 17 Jul 2024
Brosda Sandra, Aoude Lauren G, Bonazzi Vanessa F, Patel Kalpana, Lonie James M, Belle Clemence J, Newell Felicity, Koufariotis Lambros T, Addala Venkateswar, Naeini Marjan M, Pearson John V, Krause Lutz, Waddell Nicola, Barbour Andrew P
Abstract excerpt
BACKGROUND: Oesophageal adenocarcinoma (OAC) is a highly heterogeneous cancer with poor survival. Standard curative treatment is chemotherapy with or without radiotherapy followed by oesophagectomy. Genomic heterogeneity is a feature of OAC and has been linked to treatment resistance. METHODS: Whole-genome sequencing data from 59 treatment-naïve and 18 post-treatment samples from 29 OAC patients was analysed....
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